Ryan Martinie

Ryan Martinie received his B.S. in biochemistry and biology from Calvin College in 2013. He then continued his studies at Pennsylvania State University as a National Science Foundation Graduate Research Fellow and graduated with his Ph.D. in chemistry in 2018, followed by postdoctoral research at Princeton University. His research interests concern how enzymes utilize metal atoms to perform difficult chemical reactions, how bacteria utilize these enzymes to produce complex molecules, and discovering new molecules with potential medical relevance.

Select Publications

• Caruso, A.;* Martinie, R. J.;* Bushin, L. B.; Seyedsayamdost, M. R. Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical S-Adenosylmethionine Enzymes. J. Am. Chem. Soc. 2019, 141, 16610-16614. *indicates equal contributions
• Davis, K. M.; Altmyer, M.; Martinie, R. J.; Schaperdoth, I.; Krebs, C.; Bollinger, J. M., Jr.; Boal, A. K. Structure of a ferryl mimic in the archetypal iron(II)- and 2-(oxo)-glutaratedependent dioxygenase, TauD. Biochemistry 2019, 58, 4218-4223.
• Gumkowski, J. D.; Martinie, R. J.; Corrigan, P. S.; Pan, J.; Bauerle, M. R.; Almarei, M.; Booker, S. J.; Silakov, A.; Krebs, C.; Boal, A. K. Analysis of RNA methylation by phylogenetically diverse Cfr radical SAM enzymes reveals an iron-binding accessory domain in a clostridial enzyme. Biochemistry 2019, 58, 3169-3184.
• Caruso, A.; Bushin, L. B.; Clark, K. A.; Martinie, R. J.; Seyedsayamdost, M. R. A Radical Approach to Enzymatic β-Thioether Bond Formation. J. Am. Chem Soc. 2019, 141, 990-997.
• Martinie, R. J.; Blaesi, E. J.; Krebs, C.; Bollinger, J. M., Jr.; Finkelstein, K.; Pollock, C. J. Two- Color Valence-to-Core X-ray Emission Spectroscopy Tracks Cofactor Protonation State in a Class I Ribonucleotide Reductase. Angew. Chem. Int Ed. 2018, 57, 12754–12758.

Appointed to the Faculty

Educational Background

Ph.D., Pennsylvania State University
B.S., Calvin College